Primary Prevention of Coronary Artery Disease

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Abstract
The development and progression of atherosclerosis is an intricate inflammatory process dependent on intimal entry of low-density lipoprotein (LDL) cholesterol. Although myriad genetic and environmental factors modulate this process, the centrality of LDL cholesterol to the physiology of plaque genesis, progression, and instability leads to the notion that reducing serum LDL cholesterol might be an effective way to mitigate or even prevent the disease.A number of clinical trials have unequivocally demonstrated the clinical utility of lowering LDL cholesterol levels. The three major cholesterol-lowering trials carried out in people without a history of coronary events (primary prevention trials) include the . . .