DIFFERENTIAL SENSITIVITY OF A AND C NERVE FIBRES TO LONG-ACTING AMIDE LOCAL ANAESTHETICS

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Abstract
The differential sensitivities of A β, A δ and C fibres of rat vagus nerve to bupivacaine, etidocaine and AL-381 were studied in vitro. In A β fibres, at 35—37°C, 50μmole litre−1of the drugs had similar effect on the action potential amplitude, while at greater concentrations (100 and 200 μmole litre−1) the greatest mean depression of amplitude was seen with etidocaine (n.s.) AL-381 had the most marked effect on the A δ potentials, and it appeared that it was about twice as potent as the others in blocking these fibres. Etidocaine 100 μmole litre−1 was more depressant than the same dose of bupivacaine. The C fibres were blocked most rapidly by AL-381, while etidocaine had the least effect