Synthesis of 2′,5′-Dideoxy-adenosine-3′-monophosphate Derivatives as Allosteric Inhibitors of Adenylyl Cyclase
- 1 August 1995
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 14 (6) , 1453-1460
- https://doi.org/10.1080/15257779508010705
Abstract
The synthesis of a fluorescent and a lipophilic conjugate of 2′,5′-dideoxy-3′-AMP, an allosteric inhibitor of adenylyl cyclase, has been devised.Keywords
This publication has 13 references indexed in Scilit:
- O-selective phosphorylation of nucleosides without N-protectionThe Journal of Organic Chemistry, 1993
- Mode of action of 5'-linked cholesteryl phosphorothioate oligodeoxynucleotides in inhibiting syncytia formation and infection by HIV-1 and HIV-2 in vitroBiochemistry, 1991
- Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitorsTrends in Pharmacological Sciences, 1990
- Cholesteryl-conjugated oligonucleotides: synthesis, properties, and activity as inhibitors of replication of human immunodeficiency virus in cell culture.Proceedings of the National Academy of Sciences, 1989
- Synthesis of alkylating oligonucleotide derivatives containing cholesterol or phenazinium residues at their 3′‐terminus and their interaction with DNA within mammalian cellsFEBS Letters, 1989
- Topographical analysis of trypsin active site structure by means of the “inverse substrate” methodBioorganic Chemistry, 1987
- Synthesis of 5′-alkylthio-5′-deoxynucleosides from nucleosides in a one-pot reactionJournal of the Chemical Society, Perkin Transactions 1, 1983
- Convenient preparation of 5'-chloro-2',5'-dideoxyadenosineThe Journal of Organic Chemistry, 1979
- A convenient synthesis of 5′-deoxyribonucleosidesCarbohydrate Research, 1977
- Internucleotide cleavage during unblocking in oligonucleotide synthesis by the phosphotriester approachTetrahedron Letters, 1974