Effects of Phenolic Constituents from the Mulberry Tree on Arachidonate Metabolism in Rat Platelets

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Abstract
The effects of various phenolic compounds isolated from the rootbark of the mulberry tree of rat platelet cyclooxygenase and lipoxygenase products formed from (1-14C)arachiodonic acid were studied. Kuwanons G and H, sanggenon C, and mulberrofuran Q at concentrations of 10-3 to 10-4 M inhibited the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase products); however, they incresaed the formation of 12-hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) (a lipoxygenase product). Sanggenon D and mulberrofuran J at concentration of 10-3 M inhibited the formation of HHT, thromboxane B2, and 12-HETE, while at 10-5, it inhibited the formation of 12-HETE without affecting the formations of HHT and thromboxane B2. Kuwanon M and mulberroside A did not affect arachidonate metabolism in rat platelets.