Determination of Ki67 Growth Fraction and Oestrogen Receptors In Screen‐Detected Breast Cancer Using Cytological Preparations

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Abstract
Oestrogen receptor (ER) status of 77 cases of screen‐detected breast cancer has been determined using cytological preparations. In 48% ER status was positive, which was the same proportion as that formed in a control group of age‐matched patients with symptomatic breast carcinoma. Since the screen‐detected group contained more low grade tumours, the percentage of ER‐positive cases would be expected to be higher. the reasons for the discrepancy are discussed. Ki67 score has been determined for 41 cases of screen‐detected cancer. Ki67 score showed a positive correlation with histological tumour grade and a negative correlation with ER status. However, there was no correlation with tumour size or lymph node status. the Ki67 scores in the screen‐detected cancers were essentially similar to those found in an age‐matched symptomatic group, but the very low scores were only found in the screened group.