Macroglobulins and the Sia Water Test

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Abstract
The serum of a patient with Waldenstrom''s macroglobulinemia did not yield a positive Sia water test (euglobulin test). Macroglobulins which migrate electrophoretically with the gamma2 globulins usually have a positive Sia water test, whereas this test is likely to be negative in macroglobulins of greater electrophoretic mobility. The macroglobulin under discussion belongs within the second group as [beta]2-(gamma1) globulin. The difference in water solubility is probably not associated with the amino-acid composition of the protein but with the quality of the sialic acid component and its interaction with other sialic acid-containing glycoproteins.