Mechanisms of Leukocyte Production and Release

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Abstract
Leukocyte release from isolated perfused femurs of rats with the Shay chloroleukemia was determined and compared with normal preparations. Histological studies show that alterations in femoral marrow vasculature developing during the course of the leukemia prevented physiological perfusions. Increased cellular release and augmented flow rates were due to artificial pathways created by abnormally high perfusion pressures. High peripheral circulating levels of leukocytes in the late stages of the Shay chloroleukemia were attributed to extramedullary sites of cell production and release.

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