Inhibitory Effect of Gliclazide on Platelet Adhesiveness and Aggregation in Alloxan Diabetic Rabbits

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Abstract
The inhibitory effect of gliclazide, a new sulfonylurea, on platelet function was examined in alloxan diabetic rabbits. The blood glucose level in diabetic rabbits was about 3 .times. higher than in normal rabbits, and the plasma insulin level was below 50% of that of normal rabbits. Platelet adhesiveness to glass beads and platelet aggregation by collagen were markedly enhanced in the diabetic rabbits. Administration 2-4 wk daily of gliclazide (100 mg/kg, orally) to diabetic rabbits effected the reduction of enhanced platelet adhesiveness, and platelet aggregation was also lowered to that of normal rabbits after 4 wk. Blood glucose and plasma insulin levels were not changed by the treatment. Gliclazide may exert an inhibitory action on platelet function via mechanism(s) other than insulin secretion and glucose metabolism.