Peptidyltransferase center of ribosomes
- 22 August 1983
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 160 (1-2) , 129-133
- https://doi.org/10.1016/0014-5793(83)80951-x
Abstract
The molecular mechanism of action of the alkaloid lycorine has been revised. According to our results, lycorine inhibits the binding of CACCA‐Leu←Ac to the donor site of the peptidyltranferase center of wheat‐germ ribosomes, whereas the transpeptidation reaction in the system with the minimal model donor is not inhibited. The equilibrium constant of CACCA‐Leu←Ac to the donor site of 80 S ribosomes is measured.Keywords
This publication has 13 references indexed in Scilit:
- The donor site of the peptidyltransferase center of ribosomesFEBS Letters, 1979
- Ribosomes of rat liver catalyze ‘minimal’ donor reactionFEBS Letters, 1979
- Peptidyl transferase activity in wheat germ ribosomesBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1977
- Synthesis of acylamino acid esters of nucleoside 5′-phosphates and their investigation with PMR and CD spectraNucleic Acids Research, 1977
- Inhibitors of protein synthesis in eukaryotic cellsBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1976
- The study of the stimulating mechanism of the peptidyl donor activity of 2′(3′)‐O‐(N‐formylmethionyl)‐adenosine‐5′‐phosphate in peptidyl transferase of E. coli ribosomeFEBS Letters, 1976
- Narciclasine: an antitumour alkaloid which blocks peptide bond formation by eukaryotic ribosomesFEBS Letters, 1975
- [3H]anisomycin binding to eukaryotic ribosomesJournal of Molecular Biology, 1974
- Inhibitors of protein synthesisFEBS Letters, 1974
- Ribosome-catalysed reaction of puromycin with a formylmethionine-containing oligonucleotideJournal of Molecular Biology, 1967