Activation of Integrin Function by Nanopatterned Adhesive Interfaces
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- 10 March 2004
- journal article
- research article
- Published by Wiley in Chemphyschem
- Vol. 5 (3) , 383-388
- https://doi.org/10.1002/cphc.200301014
Abstract
Sticky dots: To study the function behind the molecular arrangement of single integrins in cell adhesion, the authors designed a hexagonally close‐packed rigid template of cell adhesive gold nanodots by means of micellar diblock copolymer lithography. A critical separation length of ≥73 nm between the adhesive dots dramatically reduces cell functions due to restricted integrin clustering (see picture). The range between 58–73 nm is proposed to be a universal length scale for integrin clustering and activation, since these properties are shared by a variety of cultured cells lines.Keywords
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