Anticoagulants

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Abstract
DicumarolIn 1922 Schofield44 described a hemorrhagic disease in cattle fed spoiled sweet-clover hay. Roderick45 found that the basic defect in sweet-clover disease was prothrombin deficiency and that the hemorrhagic tendency could be controlled by a withdrawal of the diet of spoiled hayand transfusion of fresh blood from healthy cattle. In 1934 Link and his collaborators at the University of Wisconsin Agricultural Experiment Station initiated an intensive search for the causative agent in spoiled sweet clover. By 1940 the active principle had been isolated in crystalline form,46 and shortly thereafter it was identified by synthesis as 3,3′-methylenebis (4-hydroxycoumarin), now known . . .
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