Urinalysis of minor metabolites of ethylbenzene and m-xylene.

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Abstract
Gas chromatographic methods have been developed for the urinalysis of metabolic products of ethylbenzene [found in the workplace]. Minor metabolites were emphasized in this process. The methods were worked out so that simultaneous determination of several compounds could be achieved with 1 method. On the whole, 4 assays are described, which together allow 12 different compounds [including acetophenone, 2,4-dimethylphenol, 4-ethylphenol, hydroxyacetophenones, 3-methylbenzyl-alcohol, phenylacetic acid, 1-phenyl-1,2-ethanediol, 1-phenylethanol, phenylglyoxal and phenylglyoxylic acid] to be measured. Since 1 of the methods presented can be applied to determine "minor" metabolites of xylene as well, methodological data for these are also reported. The methods described have successfully been used in metabolic studies of ethylbenzenes in rat and man.

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