Chemically Modified Solid-State Nanopores
Top Cited Papers
- 16 May 2007
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 7 (6) , 1580-1585
- https://doi.org/10.1021/nl070462b
Abstract
Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used to fabricate synthetic nanopores in thin solid-state membranes with subnanometer resolution. Here we report a new class of chemically modified nanopore sensors. We describe two approaches for monolayer coating of nanopores: (1) self-assembly from solution, in which nanopores ∼10 nm diameter can be reproducibly coated, and (2) self-assembly under voltage-driven electrolyte flow, in which we are able to coat 5 nm nanopores. We present an extensive characterization of coated nanopores, their stability, reactivity, and pH response.Keywords
This publication has 37 references indexed in Scilit:
- Transport of α-Helical Peptides through α-Hemolysin and Aerolysin PoresBiochemistry, 2006
- Orientation discrimination of single-stranded DNA inside the α-hemolysin membrane channelProceedings of the National Academy of Sciences, 2005
- Nanopore Unzipping of Individual DNA Hairpin MoleculesBiophysical Journal, 2004
- Unzipping Kinetics of Double-Stranded DNA in a NanoporePhysical Review Letters, 2003
- Stochastic sensors inspired by biologyNature, 2001
- Voltage-Driven DNA Translocations through a NanoporePhysical Review Letters, 2001
- Simultaneous stochastic sensing of divalent metal ionsNature Biotechnology, 2000
- Rapid nanopore discrimination between single polynucleotide moleculesProceedings of the National Academy of Sciences, 2000
- Microsecond Time-Scale Discrimination Among Polycytidylic Acid, Polyadenylic Acid, and Polyuridylic Acid as Homopolymers or as Segments Within Single RNA MoleculesPublished by Elsevier ,1999
- Characterization of individual polynucleotide molecules using a membrane channelProceedings of the National Academy of Sciences, 1996