Abstract
The 4-day-old newborn rats failed to respond to a single injection of epinephrine with adrenal ascorbic acid depletion. Adrenalectomy of pregnant rats causes a relative hypertrophy of the adrenal glands of their newborn young. The 3-to 4-day-old newborn young of the adrenalectomized mother respond to epinephrine with a highly significant decrease of the adrenal ascorbic acid concentration.