The antihypertensive effect of indapamide in low doses

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Abstract
A dose-titration study was performed to assess the minimal antihypertensive dose of indapamide and the dose-response curve in ambulatory patients with mild essential hypertension (diastolic blood pressure 90 to 114 mmHg). After a 30-day placebo period, patients received 0.5 mg indapamide daily for 6 weeks and this was increased to 1.0 mg daily for a further 6 weeks in those not responding, i.e. with a standing diastolic pressure greater than 90 mmHg. Although indapamide demonstrated an antihypertensive effect at these dose levels, normalization of blood pressure was achieved in only 2 of the 13 patients on 0.5 mg per day and in none of the 11 patients receiving 1.0 mg per day. No clinical side-effects or abnormalities in serum potassium and uric acid were noted.