The spectrum of low molecular weight house dust mite (Dermatophagoides pteronyssinus) allergens with emphasis on Der p II

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Abstract
Analysis by protein blotting of sera from 96 different house dust mite-allergic subjects revealed previously unrecognized complexity of low molecular weight (MW)(<20 kD) IgE-binding proteins in extracts of whole bodies of Dermatophagoides-pteronyssinus. Of 11 different IgE-binding components of MW <20 kD identified, two (MW .apprx. 16 kD and .apprx. 15 kD), showed both a high frequency (88% and 49% respectively) and a high intensity of IgE-binding. The .apprx. 16 kD component, identified as allergen Der p II, showed the highest frequency of IgE antibody reactivity of any of the major D. pteronyssinus allergens including Der p I and Der p II.