Molecular regulation of HDL metabolism and function: implications for novel therapies
Top Cited Papers
Open Access
- 1 December 2006
- journal article
- review article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 116 (12) , 3090-3100
- https://doi.org/10.1172/jci30163
Abstract
HDL metabolism represents a major target for the development of therapies intended to reduce the risk of atherosclerotic cardiovascular disease. HDL metabolism is complex and involves dissociation of HDL apolipoprotein and HDL cholesterol metabolism. Advances in our understanding of the molecular regulation of HDL metabolism, macrophage cholesterol efflux, and HDL function will lead to a variety of novel therapeutics.Keywords
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