Fate of Orally Ingested Enzymes in Pancreatic Insufficiency

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Abstract
To assess the fate and efficacy of orally ingested enzymes in pancreatic insufficiency, we administered pancreatin to six patients by two schedules — eight tablets with a standard meal or two tablets hourly — and in six normal controls, quantified duodenal enzyme activity and related inactivation of ingested enzymes to gastric and duodenal pH; in the six patients we measured malabsorption by fecal balance studies.