Scanning tunnelling microscopy of Z-DNA
- 1 June 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 339 (6224) , 484-486
- https://doi.org/10.1038/339484a0
Abstract
Scanning tunnelling microscopy (STM) has been used to map the surface topography of inorganic materials at the atomic level, and is potentially one of the most powerful techniques for probing biomolecular structure. Recent STM studies of calf thymus DNA and poly(rA).poly(rU) have shown that the helical pitch and periodic alternation of major and minor grooves can be visualized and reliably measured. Here we present the first STM images of poly(dG-me5dC).poly(dG-me5dC) in the Z-form. Both the general appearance of the fibres and measurements of helical parameters are in good agreement with models derived from X-ray diffraction.Keywords
This publication has 11 references indexed in Scilit:
- Scanning Tunneling Microscopy of Nucleic AcidsScience, 1989
- Direct Observation of Native DNA Structures with the Scanning Tunneling MicroscopeScience, 1989
- Scanning Tunneling Microscopy and Atomic Force Microscopy: Application to Biology and TechnologyScience, 1988
- Length, mass, and denaturation of double-stranded RNA molecules compared with DNABiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1987
- The Tunneling Microscope: A New Look at the Atomic WorldScience, 1986
- 7 × 7 Reconstruction on Si(111) Resolved in Real SpacePhysical Review Letters, 1983
- Molecular structure of (m5dC-dG)3: the role of the methyl group on 5-methyl cytosine in stabilizing Z-DNANucleic Acids Research, 1982
- Molecular electrostatic potential of the nucleic acidsQuarterly Reviews of Biophysics, 1981
- Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).Proceedings of the National Academy of Sciences, 1981
- High-salt d(CpGpCpG), a left-handed Z′ DNA double helixNature, 1980