THE EFFECT OF SOMATOSTATIN ON FASTING AND POSTPRANDIAL PLASMA GIP, SERUM-INSULIN, AND BLOOD-GLUCOSE IN MAN

  • 1 January 1981
    • journal article
    • research article
    • Vol. 16  (1) , 113-119
Abstract
Six healthy men were given a standard breakfast, one day with and another day without a 2 h 100 .mu.g/h somatostatin infusion. During the somatostatin infusion the meal-induced responses of plasma GIP (gastric inhibitory polypeptide) and serum insulin were completely blocked, whereas the rise in blood glucose was significantly augmented. After termination of the somatostatin infusion the mean plasma GIP increased gradually to a peak after 2 h, whereas mean serum insulin showed a marked rebound phenomenon and peaked after 30 min, and mean blood glucose fell to an apparent nadir after another 30 min. The effect of somatostatin on basal plasma GIP, serum insulin, blood glucose and gastric H+ secretion was studied in another group of 6 healthy men. Mean plasma GIP tended to fall during the initial 1 h saline infusion, fell further during the 1st part of the 2 h 100 .mu.g/h somatostatin infusion and started to rise first 85 min after termination of the somatostatin infusion. Similarly, mean serum insulin, mean blood glucose and mean gastric H+ secretion decreased during the somatostatin infusion, and thereafter returned to their basal levels.