RESTRICTION ENDONUCLEASE CLEAVAGE ANALYSIS OF ADENOVIRUS TYPE 8: TWO NEW SUBTYPES FROM PATIENTS WITH EPIDEMIC KERATOCONJUNCTIVITIS IN SAPPORO, JAPAN

Abstract
The restriction endonuclease cleavage patterns of the DNA of adenovirus type 8 (Ad 8) isolated from epidemic keratoconjunctivitis cases were studied. DNA of 25 Ad 8 isolates collected from 1975 to 1981 in Sapporo [Japan] were subjected to enzymatic cleavage with PstI, BamHI, HindIII and SalI. On the basis of the cleavage patterns, the isolates were divided into 2 subtypes, A and B, both different from the Trim strain used as the Ad 8 prototype strain. Subtype A was prevalent from 1975-1978, while subtype B was prevalent from 1976-1981.

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