Immunological Responses to Candida albicans I. Mouse-Thigh Lesion as a Model for Experimental Candidiasis
- 1 June 1974
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 9 (6) , 999-1002
- https://doi.org/10.1128/iai.9.6.999-1002.1974
Abstract
A mouse-thigh lesion model for experimental candidiasis is described. A standard inoculum of 5 × 10 8 yeast cells of Candida albicans , injected into the thigh muscle of C57BL/Ks mice, produced an easily measured thigh lesion that was self-limiting by 4 to 6 weeks, permitting a study of immunological responses to the infection. Examination of the histopathology of the lesion reveals that the cellular infiltrate is predominately granulocytic, and gives little evidence for an active, specific, cell-mediated immune response.Keywords
This publication has 8 references indexed in Scilit:
- Lymphokine Toxicity for Yeast CellsThe Journal of Immunology, 1973
- Chronic Mucocutaneous Candidiasis: Model-Building in Cellular ImmunityAnnals of Internal Medicine, 1971
- Measurement of Candidacidal Activity of Specific Leukocyte Types in Mixed Cell Populations I. Normal, Myeloperoxidase-Deficient, and Chronic Granulomatous Disease NeutrophilsInfection and Immunity, 1970
- Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infectionJournal of Clinical Investigation, 1969
- Defective cellular immunity associated with chronic mucocutaneous moniliasis and recurrent staphylococcal botryomycosis: immunological reconstitution by allogeneic bone marrow.1968
- Passive immunization of mice againstCandida albicansMedical Mycology, 1968
- The Process of Invasion and the Persistence of Candida Albicans Injected Intraperitoneally Into MiceThe Journal of Infectious Diseases, 1958
- A MEASURABLE TUBERCULOUS LESION IN THE THIGH OF THE MOUSE1954