Effects of pentobarbital on hypothalamic catecholamines and LRH activities
- 1 September 1980
- journal article
- research article
- Published by Bioscientifica in Acta Endocrinologica
- Vol. 95 (1) , 1-6
- https://doi.org/10.1530/acta.0.0950001
Abstract
Pentobarbital (Pnt) injection at 12.30 h to ovariectomized rats suppressed the LRH [luteinizing hormone-releasing hormone, luliberin] contents of the medial basal hypothalamus (MBH) in association with a significant fall in serum LH [lutropin] 60-90 min later. The LRH contents in the preoptic area (POA) were unchanged in Pnt treated rats. A similar effect on LRH levels in the MBH was also evident in ovariectomized rats pre-treated with estradiol benzoate. Pnt administration rapidly reduced the noradrenergic (NE) turnover in the MBH and POA, whereas dopamine (DA) turnover was unaltered. The apparent decrease in LRH secretion (release + contents) following Pnt treatment was associated with a fall in the hypothalamic NE neurotransmission, and LRH neurons and fibers in the MBH alone respond to Pnt treatment.This publication has 12 references indexed in Scilit:
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