A comparison of the central actions of prostaglandins A1, E1, E2, F1?, and F2? in the rat
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 50 (1) , 89-94
- https://doi.org/10.1007/bf00634161
Abstract
The effect of prostaglandins (PGs) A1, E1, E2, F1α, and F2α administered intraventricularly at doses of 0.02–4.0 μg/rat were studied in some behavioral, antinociceptive and anticonvulsant tests in rats. Exploratory and locomotor activity were decreased by all PGs except A1 and F2α which had no effect on locomotor activity. All PGs studied, except A1, induced hyperthermia and afforded protection in the ‘hot-plate’ analgesic test and against maximal electroshock seizures.This publication has 26 references indexed in Scilit:
- Decreased antinociceptive effect of morphine in rats treated intraventricularly with prostaglandin E1Psychopharmacology, 1974
- Further studies on prostaglandin E1 fever in catsThe Journal of Physiology, 1971
- Isolation and Identification of Prostaglandins from Ram Seminal Plasma. Prostaglandins and Related Factors 55.Acta Chemica Scandinavica, 1966
- Effects of intraventricular and intrahypothalamic injection of noradrenaline and 5‐HT on body temperature in conscious rabbits.The Journal of Physiology, 1965
- The isolation and determination of prostaglandins in lungs of sheep, guinea pig, monkey and manBiochemical Pharmacology, 1965
- Autoradiographic distribution studies of 3h-labeled prostaglandin e1 in mice. prostaglandins and related factors 31Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
- PROSTAGLANDINS IN BRAIN AND THE RELEASE OF PROSTAGLANDIN-LIKE COMPOUNDS FROM THE CAT CEREBELLAR CORTEXCanadian Journal of Physiology and Pharmacology, 1965
- Effects on temperature of amines injected into the cerebral ventricles. A new concept of temperature regulationThe Journal of Physiology, 1964
- Smooth muscle stimulating lipids in sheep iris. The identification of prostaglandin F2a. Prostaglandins and related factors 21.Biochemical Pharmacology, 1964
- The Isolation of Prostaglandin E from Sheep Prostate Glands.Acta Chemica Scandinavica, 1960