METABOLISM OF MUCOPOLYSACCHARIDES IN CONNECTIVE TISSUE. I. STUDIES OF ENZYMES INVOLVED IN GLUCURONIDE METABOLISM*

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Abstract
Enzymes involved in the synthesis of uridine diphosphoglucuronic acid (UDPGA) from glucose were demonstrated in extracts of the connective tissue which entered polyvinyl sponges inserted under the skin of guinea pigs, and in extracts of human synovial tissue. These included hexokinase, phosphoglucomutase, uridine diphosphoglucose pyrophosphorylase and uridine diphosphoglucose dehydrogenase. Their presence supports the contention that UDPGA is an intermediate in the synthesis of mucopolysaccharides. Glucuronosyl transferase, beta-glucuronidase and cytochrome c reductase activity was also measured in these tissues.