Postprandial changes in serum bile acids concentration and fractionation of individual bile acid by high performance liquid chromatography in normal dogs.

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Abstract
Serial determination of serum bile acids (SBA) concentration and its fractionation after feeding were performed in 8 healthy dogs. The mean preprandial SBA was 1.07 .+-. 0.91.mu.M/l. The mean SBA reached a maximum value of 10.35 .+-. 7.32 .mu.M/l at 6 hour with very rapid rise at 1 hour after feeding. There were no significant differences in any of the mean SBA values during the 1 to 8 hour postprandial period. The mean preprandial triglycerides (TG) concentration was 37.07 .+-. 13.51mg/dl. The mean TG increased rapidly after feeding and reached a maximum value of 73.53 .+-. 12.01mg/dl at 2 hour. It would appear that postprandial sample of SBA can be taken at 1 hour after feeding. Unfortunately, none of the peaks was identified in the fractionation study. An unidentified peak with a retention time near 6.4min. increased significantly in the 2 hour sample. A new unidentified peak with a retention time near 9.0min. appeared in the 2 hour sample.