Modulation of Horizontally Acquired Genes by the Hha-YdgT Proteins in Salmonella enterica Serovar Typhimurium
- 1 February 2008
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 190 (3) , 1152-1156
- https://doi.org/10.1128/jb.01206-07
Abstract
We describe a transcriptomic study of the effect of hha and ydgT mutations in Salmonella enterica serovar Typhimurium. A large number of genes showing altered expression are located in AT-rich horizontally acquired DNA sequences. Many of these genes have also been reported to be targets for H-NS. As Hha and YdgT interact with H-NS, our findings strongly suggest that Hha and/or YdgT must form complexes with H-NS when they silence these DNA regions.Keywords
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