Breakdown of the oxidized forms of coenzymes I and II by an enzyme from the central nervous system

Publisher Website
Google Scholar
Abstract
Prepns. from the mammalian central nervous system, which rapidly inactivated cozymase, inactivated also coenzyme II at 76-85% of the rate of their reaction with cozymase. Inactivation of coenzyme II, like that of cozymase, was accompanied by liberation of nicotinamide. Competition took place between the 2 coenzymes for the degrading system, and presumably, therefore, a common enzyme was responsible for the 2 reactions. Nicotinamide ribofuranoside, nicotinamide glycosides less closely related to cozymase, and several other nicotinamide derivatives were not affected by the enzyme. Dihydrocoenzymes I and II were not affected by the enzyme, and did not affect the breakdown by it of coenzymes I and n.