The Effect of Semistarvation and of Partial Hepatectomy on the Formation of Histamine in the Rat

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Abstract
When the histamine content of the diet is increased 100-fold, the histidine decarboxylase activity in the liver of rats is reduced whereas that in the pyloric stomach is increased. During a period of semistarvation using either a high or a low histamine diet, the histidine decarboxylase activity in both the liver and the pyloric stomach of rats is reduced. When rats are given free access to diet after a period of semistarvation using either a high or a low histamine diet, the histidine decarboxylase activity in the pyloric stomach of rats is markedly increased and no ill-effects are caused. After partial hepatectomy in rats, the histidine decarboxylase activity of the residual liver is always reduced. On the first postoperative day, an increase in urinary histamine occurs but it is followed by a much reduced output. No simple relationship exists between histamine formation in rats and growth of the regenerating liver.