Simultaneous Measurement of the Appearance and Disappearance of T-1824 (Evans Blue) in Blood and Tissue After Intravenous Injection in Man

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Abstract
After intraven. injn. of T-1824 into man, the dye can be detected in tissue from which blood is excluded, and its appearance and disappearance in "bloodless" tissue can be followed by the absolute-reading type of ear oximeter. The dye was detectable in "bloodless" ear tissue of 8 normal subjects within 2 hrs. after intraven. injn. of the dye, and max. concn. was attained on an avg. in 36 hrs. These changes were found in both cartilaginous and noncartilaginous ear tissue. At the time of max. concn. of T-1824 in "bloodless" tissues, the serum dye had fallen to approx. 50% of its max. value. Thereafter serum and tissue dye content decreased slowly; tissue content was reduced to 50% of its max. value 18 days after injn. The dye had practically disappeared from the "bloodless" tissue 60 days after injn. Owing probably to the higher sensitivity obtainable for serum detn., T-1824 was detectable in blood serum for 100 days after injn. From the time of attainment of the max. tissue dye content, which probably represents the point of attainment of equilibrium between serum and tissue dye (36 hrs. after injn.), the time for 50% decrease in concn. of T-1824 in serum was 5 1/2 days, and in tissue 16 1/2 days.
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