THE DISAPPEARANCE OF T-1824 AND STRUCTURALLY RELATED DYES FROM THE BLOOD STREAM

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Abstract
From a correlation of the disappearance rates of T-1824, T-1836 (trypan blue), D-1824 (niagara sky blue 6B), and D-1836 (niagara sky blue) with Rawsons (1942) studies of dye-protein binding, it is concluded that the difference in disappearance of these dyes from the blood stream is detd. by the strength of the bond which is formed between the dye and plasma albumin. Although the dyes are closely related structurally they ex-hibit remarkable differences in behavior which are clearly related to their differences in structure. The various lines of evidence which are cited suggest that T-1824 is so firmly bound to the albumin that the disappearance rate of this dye during the first hr. after injn. is a measure of the rate of escape of the circulating albumin. The disappear-ance curve of the dye should then follow a semilog function. This prediction is believed confirmed by a critical examina-tion of time-cone. curves obtained on normal dogs.