The effect of ergosterol and ergocalciferol on the anaerobic glycolysis of rat-liver slices

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Abstract
The use of propylene glycol, Tween 80 and lecithin for producting aqueous solutions of ergosterol was investigated. The effect of the above substances on the anaerobic glycolysis rate of rat-liver slices was studied: 0 - .01% (v/v) Tween 80 and 1% propylene glycol show appreci-able inhibition of glycolysis, whereas lecithin up to 0.36% has no effect. Solutions of ergosterol and ergocalciferol in aqueous lecithin were used to investigate the effect of these sterols on the anaerobic glycolysis rate of rat-liver slices; there is increasing inhibition of glycolysis with concentration, for the range 10-3 - 10-2 [mu]/ml, ergosterol having a greater effect on male tissue, and ergocalciferol a greater effect on female tissue. The spectra of aqueous ergosterol and ergo-calciferol solutions were investigated, after incubation with rat-liver slices.