INFLUENCE OF HYDROXYUREA AND COLCHICINE ON GROWTH AND MORPHOLOGY OF TRYPANOSOMA-CRUZI

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 35  (3) , 229-237
Abstract
Cultures of T. cruzi were exposed to hydroxyurea and colchicine. Hydroxyurea (200 .mu.g/ml) completely inhibited growth and differentiation of T. cruzi Y strain. Colchicine (200 .mu.g/ml) reduced the growth of T. cruzi 30%, stimulated cell differentiation from epimastigotes to trypomastigotes, and caused formation of anuclear cells with apparently intact kinetoplasts. The possible use of these anuclear forms in studies on kinetoplast DNA organization and expression is suggested.