Total synthesis of bovine pancreatic ribonuclease A. Part 2. Synthesis of the protected hexatriacontapeptide ester (positions 89–124)
- 1 January 1981
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 797-803
- https://doi.org/10.1039/p19810000797
Abstract
Commencing with the protected C-terminal pentadecapeptide of bovine pancreatic RNase,Z(OMe)-(RNase 110–124)-OBzl, chain elongation was accomplished to form the hexatriacontapeptide, Z(OMe)-(RNase 89–124)-OBzl, by six successive azide condensations of the peptide fragments, Z(OMe)-Val-Ala-NHNH2(4), Z(OMe)-Ile-Ile-NHNH2(5), Z(OMe)-Asn-Lys(Z)-His-NHNH2(6), Z(OMe)-Lys(Z)-Thr-Thr-Gln-Ala-NHNH2(7), Z(OMe)-Tyr-Pro-Asn-Cys(MBzl)-Ala-Tyr-NHNH2(8), and Z(OMe)-Ser-Ser-Lys(Z)-NHNH2(9).This publication has 6 references indexed in Scilit:
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