Case report: Kinetics of Epstein-Barr virus load in a bone marrow transplant patient with no sign of lymphoproliferative disease
- 16 December 2002
- journal article
- case report
- Published by Wiley in Journal of Medical Virology
- Vol. 69 (2) , 220-224
- https://doi.org/10.1002/jmv.10285
Abstract
The kinetics of Epstein-Barr virus (EBV) load was measured in peripheral blood mononuclear cells of a severely immunocompromised allogeneic bone marrow recipient child, in conditions not associated with lymphoproliferative disease. The viral doubling time was 46.4 hr. The study permitted monitoring EBV clearance from blood, when the anti-rejection therapy was interrupted. Likely, this is the first accurate kinetic assessment of EBV load increasing phase in a clinical context marked by the absence of an overt post-transplant lymphoproliferative disease. According to these data gamma-herpesviruses behave like beta-herpesviruses in being capable of rapid growthKeywords
Funding Information
- ISS (40C.68)
- CNR (01.00777.PF49)
- MURST
This publication has 7 references indexed in Scilit:
- PATIENTS AT RISK FOR DEVELOPMENT OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER: PLASMA VERSUS PERIPHERAL BLOOD MONONUCLEAR CELLS AS MATERIAL FOR QUANTIFICATION OF EPSTEIN-BARR VIRAL LOAD BY USING REAL-TIME QUANTITATIVE POLYMERASE CHAIN REACTION1,2Transplantation, 2001
- Diagnosis and Management of Posttransplant Lymphoproliferative Disorder in Solid‐Organ Transplant RecipientsClinical Infectious Diseases, 2001
- Toward Standardization of Epstein-Barr Virus DNA Load Monitoring: Unfractionated Whole Blood as Preferred Clinical SpecimenJournal of Clinical Microbiology, 2001
- Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patientsBlood, 2001
- Application of viral-load kinetics to identify patients who develop cytomegalovirus disease after transplantationThe Lancet, 2000
- Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α TherapyScience, 1998
- Presence of Epstein-Barr virus latency type III at the single cell level in post-transplantation lymphoproliferative disorders and AIDS related lymphomas.Journal of Clinical Pathology, 1997