Straightforward Synthesis of 1-(2,3-Dideoxy-β-D-Glycero-Pent-2-Enofuranosyl)-Thymine
- 1 May 1994
- journal article
- other
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 13 (4) , 1011-1013
- https://doi.org/10.1080/15257779408011874
Abstract
A two steps synthesis of the antiviral drug (d4T) 3 from thymidine 1 is proposed, which implies a concomitant deprotection-elimination process by action of t-BuOK in DMF on 5′-O-t-butyldimethylsylil-3′-O-methanesulfonyl-thymidine 2.Keywords
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