CONNECTIVE-TISSUE ACTIVATION .13. STIMULATION OF SULFATED GLYCOSAMINOGLYCAN SYNTHESIS IN HUMAN CONNECTIVE-TISSUE CELLS BY PEPTIDE MEDIATORS FROM LYMPHOCYTES AND PLATELETS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 91  (5) , 811-821
Abstract
Connective tissue-activating peptide from lymphocytes (CTAP-I) and CTAP-III from platelets markedly stimulated 36SO42- incorporation into chrondroitin 4/6 sulfate and dermatan sulfate synthesized by human synovial, dermal and cartilage connective tissue cells in vitro. These agonists promoted synthesis of the GAG [glycosaminoglycan] carbon chain as well as sulfate incorporation. Both RNA and protein synthesis were required for these mediators to be effective in stimulating synthesis of connective tissue matrix components. A major part of the capacity of normal serum to stimulate sulfate incorporation into GAG may reside in CTAP-III.

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