Reduction of bladder contractility after alpha-adrenergic blockade and after ganglionic blockade

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Abstract
Spinal cord injured patients (7) were evaluated with cystometry bladder, electromyography and pressure profiles of the external urethral sphincter before and after phenoxybenzamine administration. More patients (7) were evaluated before and after mecamylamine administration. Both drugs reduced the contractility of the bladder. The reduction of bladder contractility may reflect decreased sympathetic stimulation to the bladder. Bladder electric potentials reflect the intrinsic tone of the detrusor muscle.