Narcotic Tolerance and Dependence: Lack of Relationship with Serotonin Turnover in the Brain
- 19 March 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 171 (3976) , 1169-1170
- https://doi.org/10.1126/science.171.3976.1169
Abstract
Serotonin turnover was measured in mouse brain by means of the conversion of radioactivity from labeled tryptophan into serotonin. Animals with a high degree of tolerance to and physical dependence on morphine did not differ from control mice.Keywords
This publication has 3 references indexed in Scilit:
- In vivo Conversion of3H-L-Tryptophan into3H-Serotonin in Brain Areas of Adrenalectomized RatsScience, 1970
- Morphine Tolerance, Physical Dependence, and Synthesis of Brain 5-HydroxytryptamineScience, 1968
- Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletorPsychopharmacology, 1968