Mouse models with modified p53 sequences to study cancer and ageing
- 28 April 2003
- journal article
- review article
- Published by Springer Nature in Cell Death & Differentiation
- Vol. 10 (4) , 443-450
- https://doi.org/10.1038/sj.cdd.4401188
Abstract
Experiments with p53 transgenic and p53 gene-targeted mouse strains have substantiated, and in some cases challenged, a number of hypotheses on the biology of the p53 protein. New questions have emerged regarding similarities and differences between murine and human genetic networks in various tissues. Mouse models with targeted p53 alleles are now applied not only to investigate tumour susceptibility, but also to address questions pertinent to molecular epidemiology, chemoprevention, development of anticancer p53-specific pharmaceuticals, and ageing.Keywords
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