A Facile Access to (R)-Methyl 2-Oxocyclopentane-1-acetateviaLipase-Catalyzed Irreversible Transesterification
- 1 September 1992
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 22 (18) , 2717-2722
- https://doi.org/10.1080/00397919208021673
Abstract
A highly efficient kinetic resolution of (±)-methyl trans-2-hydroxycyclopentane-1-acetate via lipase PS-catalyzed irreversible transesterification provides a facile and economical entry to (R)-methyl 2-oxocyclopentane-1-acetate of 96% ee, a starting material for the convergent synthesis of (+)-isocarbacyclin.Keywords
This publication has 26 references indexed in Scilit:
- A Practical Access to Optically Pure (S)-1-Octyn-3-olSynthetic Communications, 1991
- Enantioselective synthesis of siloxycyclopropanes and of ???-oxocarboxylates by asymmetric catalysisTetrahedron Letters, 1989
- Enzymatic Catalysts in Organic SynthesisScience, 1989
- General Aspects and Optimization of Enantioselective Biocatalysis in Organic Solvents: The Use of Lipases [New Synthetic Methods (76)]Angewandte Chemie International Edition in English, 1989
- A controlled synthesis of α-(E)-1-alkenyl ketones from β-keto benzyl estersTetrahedron Letters, 1989
- Microbial and Enzymatic Processes for the Production of Biologically and Chemically Useful Compounds [New Synthetic Methods (69)]Angewandte Chemie International Edition in English, 1988
- A simple synthesis of (+)-isocarbacyclin via a convergent processJournal of the Chemical Society, Chemical Communications, 1988
- Chiral synthesis of isocarbacyclin ((+)-9(0)-methano-Δ6(9α)-PGI1) intermediate via rhodium(II)-catalyzed intramolecular CH insertion reactionTetrahedron Letters, 1987
- Tetrahedron report number 203Tetrahedron, 1986
- Asymmetric synthesis of prostaglandin intermediatesJournal of the American Chemical Society, 1973