Malignant Melanoma: Specific Immunity Induced by Bacillus Calmette-Gurin in BALB/c Mice
- 5 July 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 185 (4145) , 68-69
- https://doi.org/10.1126/science.185.4145.68
Abstract
Previous treatment of BALB/c mice with bacillus Calmette-Gurin (BCG) will significantly protect them against intramuscular challenge of S-91 melanoma but not against a mammary carcinoma or a methylcholanthrene-induced sarcoma. Lymphocyte-mediated cytotoxicity studies correlate with in vivo data in showing that BCG-immune lymphocytes are specifically cytotoxic to S-91 melanoma target cells but not to the carcinoma or sarcoma target cells.Keywords
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