CENTRALLY ACTIVE PHENETHYLAMINES

  • 1 January 1975
    • journal article
    • research article
    • Vol. 1  (1) , 93-98
Abstract
The 2-C homologs of 2 potent psychotomimetic agents are described. Unlike the parent isopropylamine compounds (4-methyl-2,5-dimethoxyamphetamine and 4-bromo-2,5-dimethoxyamphetamine) these phenethylamines lead to an intoxication which is, in normal subjects, of short duration and of greatly increased sensory enhancement, but, which does not superimpose hallucinogenesis. These 2 phenethylamines, 4-methyl-2,5-dimethoxyphenethylamine and 4-bromo-2,5-dimethoxyphenethylamine, are active in man at oral levels of 0.1-0.2 mg/kg, approximately 1/10 the potency of their 3-C counterparts.

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