Investigations into the Mechanism of Pertussis Vaccine Induced Hypersensitivity

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Abstract
Depending on the dose and the route of insulin administration, alterations occur in the capillary network and the pericapillary ground substance. Intramuscular and intraperi-toneal injection of insulin provoked mast cell swelling and disruption. The ground substance alterations permitted a complete dispersion of mast cell granules. Capillary endothelium became permeable for carbon particles when subjected to stimulus. These alterations were not seen when insulin was injected intravenously. Intramuscular insulin increased the sensitivity of rats to dextran so much that even a dose as small as 37.5 [mu]g/100 g dextran provoked edema formation at the extremities.