Choline in Plasma in Children, with a study of induced choline deficiency

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Abstract
SUMMARY: The total choline content (= mainly lipid bound choline) in plasma in children is the same as in adults, or 18–32 mg%. In new born babies it is only 7–14 mg%, whereas in acute nephritis in children there is often an elevation of all lipid components of plasma including the choline containing.An attempt to provoke choline deficiency in an infant through giving large doses of glycocyamine did not, in spite of great labile methyl losses, lead to any changes of the choline content of plasma, but gave a mild fatty liver with normal choline content in the phospholipid fraction. The plasma phosphatase was slightly increased and there was a tendency to positive thymol‐ and cephalin flocculation tests but for the rest no signs of impaired liver or kidney function. A choline deficiency in man probably appears only in very unfavourable circumstances.