Effect of Flowing Adjuvants on the Homogeneity and the Kinetics of Mixing of Low Dosage Cohesive Powder Mixtures

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Abstract
One of the major problems encountered in powder mixing, depending on the properties of the constituents of the mix is the inability of low-power mixers to break down powder agglomerates The effects of the addition of two flowing ad juvants (colloidal Aluminium oxide and Aerosil-200R) on the homogeneity of cohesive powder mixtures and on the kinetics of mixing, were investigated It was demonstrated that colloidal Aluminium oxide increases the degree of homogeneity of a 1 % Triamteren-200 mesh lactose mixture blended in a Turbula T2 C mixer, when an appropriate concentration of the adjuvant, corresponding to that which produces the best flowing properties of the excipient was used. Aerosil-200R did not enhance the homogeneity of the mix
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