The Effect of Glucose Availability and Utilization on Chylomicron Metabolism in the Rat

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Abstract
Following i.v. administration of H3 palmitate labelled chylomicrons a greater amount of radioactivity was recovered from adipose tissue of refed than fasted rats and from insulin treated than insulin deprived diabetic rats. Adipose tissue uptake of label appeared to be potentiated by insulin in normal as well as in diabetic rats. No definite differences in the rate of clearing chylomicrons from blood was noted in insulin treated and insulin deprived diabetic rats. Although the enhanced adipose tissue uptake of triglyceride fatty acid might be related to the availability of α glycerophosphate for esterification it is equally possible that adipose tissue lipoprotein lipase content may be a regulating factor. Heparin, as opposed to saline administration prior to chyle injection, produced marked acceleration in the rate of removal of chyle from the blood of treated and untreated diabetic animals. The accelerated removal was related to accelerated uptake of activity by the liver and could be attributed in part to intravascular lipolysis of chyle triglyceride. The effect of heparin on the degree and the nature of hepatic uptake was no different in treated and untreated diabetic animals.