The Effect of Acute Insulin Deficiency in the Rat on Adipose Tissue Lipolytic Activity and Plasma Lipids

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Abstract
In 59 insulin treated alloxan-diabetic rats, adipose tissue lipoprotein lipase and tributyrinase activities were determined between one and 72 hours after the cessation of insulin injections. Blood glucose, plasma fatty acids, and plasma triglycerides were measured simultaneously along with the in vitro uptake of glucose by the excised diaphragm. It was shown that lipoprotein lipase activity decreased rapidly after cessation of insulin, in contrast to the relatively small change in tributyrinase activity. The rapid change in lipoprotein lipase activity exhibits an inverse correlation with blood glucose, plasma triglycerides, and fatty acids. The relationship of adipose tissue lipolytic enzymes to diabetes mellitus is discussed. It is proposed that a deficiency in lipoprotein lipase activity may contribute significantly to the elevated triglycerides of uncontrolled diabetes mellitus.