The effect of felodipine on ventricular fibrillation after coronary artery ligation in the anaesthetized pig

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Abstract
A 10 min ligation of the left anterior descending coronary artery in anaesthetized pigs resulted in ventricular fibrillation (VF) in 70% of control and propranololtreated animals. Felodipine (10 nmol kg−1) not only reduced ventricular ectopic activity by 90%, but also completely abolished VF. When a second occlusion was applied after 20 min of reperfusion, felodipine was less effective against VF, possibly due to decreasing felodipine concentrations or only a transient increase in VF threshold.