Hypovolemia in the Nephrotic Syndrome — A Contraindication to Renal Biopsy

Abstract
TO date, we have performed a total of 150 percutaneous renal biopsies in patients with various types of kidney disease, including the nephrotic syndrome. The 1 fatal case in our series occurred in 1957, when a young woman with systemic lupus erythematosus and the nephrotic syndrome died shortly after the biopsy procedure. Although blood-volume measurements were not done in this case, a review of the clinical course, together with the findings at autopsy, led us to believe that hypovolemia had been present and was a contributory factor in the patient's death. Since that time we have routinely performed blood-volume measurements . . .